| pubmed-article:7669657 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C2926606 | lld:lifeskim |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C0002886 | lld:lifeskim |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C0010802 | lld:lifeskim |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C2607943 | lld:lifeskim |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:7669657 | lifeskim:mentions | umls-concept:C0332240 | lld:lifeskim |
| pubmed-article:7669657 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7669657 | pubmed:dateCreated | 1995-10-18 | lld:pubmed |
| pubmed-article:7669657 | pubmed:abstractText | Macrocytosis in the elderly is often caused by abnormalities of haematological stem cell differentiation. In this study, a group of elderly patients was analysed for four molecular and cell biological parameters. The aim of the study was to screen elderly patients with idiopathic macrocytic anaemia or MDS for a set of alterations which are related to haematological dysplasia. The analyses used were: DNA-methylation at the calcitonin A gene 5'-area, NRAS point mutations at codons 12 and 13, in vitro colony formation of peripheral blood progenitor cells and cytogenetics of bone marrow cells. The results show that a significant portion of elderly patients with idiopathic macrocytosis have one or more of the abnormalities analysed. Hypermethylation of the calcitonin A gene 5'-area at the chromosome 11 band p15 is relatively common (7/15). Chromosomal aberrations (3/12) and NRAS oncogene point mutations (0/15) were rare findings. In vitro culture of erythroid progenitor cells was relatively frequently abnormal (7/15). Eight of our nine macrocytic patients who did not fulfill the FAB criteria for MDS had at least one of the alterations studied; this suggests that these patients might represent early phases of a stem cell disorder. | lld:pubmed |
| pubmed-article:7669657 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7669657 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7669657 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7669657 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7669657 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7669657 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7669657 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7669657 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:7669657 | pubmed:author | pubmed-author:AnttilaPP | lld:pubmed |
| pubmed-article:7669657 | pubmed:author | pubmed-author:SaloAA | lld:pubmed |
| pubmed-article:7669657 | pubmed:author | pubmed-author:JuvonenEE | lld:pubmed |
| pubmed-article:7669657 | pubmed:author | pubmed-author:PalotieAA | lld:pubmed |
| pubmed-article:7669657 | pubmed:author | pubmed-author:IhalainenJJ | lld:pubmed |
| pubmed-article:7669657 | pubmed:author | pubmed-author:HeiskanenMM | lld:pubmed |
| pubmed-article:7669657 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7669657 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:7669657 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7669657 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7669657 | pubmed:pagination | 797-803 | lld:pubmed |
| pubmed-article:7669657 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:meshHeading | pubmed-meshheading:7669657-... | lld:pubmed |
| pubmed-article:7669657 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7669657 | pubmed:articleTitle | Idiopathic macrocytic anaemia in the aged: molecular and cytogenetic findings. | lld:pubmed |
| pubmed-article:7669657 | pubmed:affiliation | Department of Internal Medicine, Helsinki City Hospital, Finland. | lld:pubmed |
| pubmed-article:7669657 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7669657 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
