Linked Life Data

7669084

Source:http://linkedlifedata.com/resource/pubmed/id/7669084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-10-6
pubmed:abstractText
Postprandial fat clearance and absorption, fecal elimination and synthesis of cholesterol, bile acid synthesis, and cholesterol precursors and plant sterols in serum were studied in five patients with type III dyslipoproteinemia off and on lovastatin. The basal values were related to those in nontreated normolipidemic control subjects with apolipoprotein E3/3 phenotype (apo E3 controls, n = 16). On regular home diets, cholesterol precursor concentrations and cholesterol precursor/cholesterol ratios were high in the type III group. However, cholesterol absorption efficiency, bile acid and cholesterol synthesis measured with sterol balance technique and the precursor sterol/plant sterol ratios in serum were similar to the control values, suggesting that cholesterol absorption and metabolism was normal in these subjects. Lovastatin normalized the increased lipoprotein concentrations and reduced biliary cholesterol secretion, absolute absorption of cholesterol, precursor sterol/cholesterol and precursor sterol/plant sterol ratios in serum, fecal neutral and total sterol outputs and cholesterol synthesis. Lovastatin had no effect on cholesterol absorption efficiency or bile acid synthesis. Despite normalization of the triglyceride-rich lipoprotein levels by lovastatin, the postprandial vitamin A and squalene peak concentrations and the areas under the curves remained above the control ranges. The findings show that in type III hyperlipidemia, the precursor sterol/cholesterol ratios do not predict cholesterol synthesis. The latter, bile acid synthesis, precursor sterol/plant sterol ratios in serum, and cholesterol absorption are normal under basal conditions. The normalization of increased lipids by lovastatin is mainly due to reduced synthesis and absolute absorption of cholesterol, while the retarded postprandial fat clearance was not normalized by the drug.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7669084-Adult, pubmed-meshheading:7669084-Apolipoprotein E3, pubmed-meshheading:7669084-Apolipoproteins E, pubmed-meshheading:7669084-Cholesterol, pubmed-meshheading:7669084-Cholesterol, Dietary, pubmed-meshheading:7669084-Cohort Studies, pubmed-meshheading:7669084-Dietary Fats, pubmed-meshheading:7669084-Eating, pubmed-meshheading:7669084-Female, pubmed-meshheading:7669084-Humans, pubmed-meshheading:7669084-Hyperlipoproteinemia Type III, pubmed-meshheading:7669084-Lipoproteins, pubmed-meshheading:7669084-Lovastatin, pubmed-meshheading:7669084-Male, pubmed-meshheading:7669084-Metabolic Clearance Rate, pubmed-meshheading:7669084-Middle Aged, pubmed-meshheading:7669084-Phenotype, pubmed-meshheading:7669084-Reference Values, pubmed-meshheading:7669084-Squalene, pubmed-meshheading:7669084-Sterols, pubmed-meshheading:7669084-Triglycerides, pubmed-meshheading:7669084-Vitamin A
pubmed:year
1995
pubmed:articleTitle
Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia.
pubmed:affiliation
Department of Medicine, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't