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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1995-10-12
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pubmed:abstractText |
Rodent tumor cells engineered to secrete cytokines such as interleukin 2 (IL-2) or IL-4 are rejected by syngeneic recipients due to an enhanced antitumor host immune response. An adenovirus vector (AdCAIL-2) containing the human IL-2 gene has been constructed and shown to direct secretion of high levels of human IL-2 in infected tumor cells. AdCAIL-2 induces regression of tumors in a transgenic mouse model of mammary adenocarcinoma following intratumoral injection. Elimination of existing tumors in this way results in immunity against a second challenge with tumor cells. These findings suggest that adenovirus vectors expressing cytokines may form the basis for highly effective immunotherapies of human cancers.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1109790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1157057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1312220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1317968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1370653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1405610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1445597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1650475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-1847722,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-2066765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-2137372,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-2212951,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/7667323-886304
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8522-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7667323-Adenocarcinoma,
pubmed-meshheading:7667323-Adenoviridae,
pubmed-meshheading:7667323-Animals,
pubmed-meshheading:7667323-Cell Line,
pubmed-meshheading:7667323-Gene Therapy,
pubmed-meshheading:7667323-Genetic Vectors,
pubmed-meshheading:7667323-Humans,
pubmed-meshheading:7667323-Immunotherapy,
pubmed-meshheading:7667323-Interleukin-2,
pubmed-meshheading:7667323-Kinetics,
pubmed-meshheading:7667323-Mammary Neoplasms, Experimental,
pubmed-meshheading:7667323-Mice,
pubmed-meshheading:7667323-Mice, Transgenic,
pubmed-meshheading:7667323-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.
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pubmed:affiliation |
Department of Biology, McMaster University, Hamilton, ON, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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