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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-10-6
|
| pubmed:abstractText |
The therapeutic use of antisense oligonucleotides will likely involve their administration over protracted periods of time. The oral route of drug dosing offers many advantages over other possible routes when chronic drug administration is necessary. However, little is known about the potential for oligonucleotide uptake from the gastrointestinal tract. This issue is addressed in the current work.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0724-8741
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
817-24
|
| pubmed:dateRevised |
2010-3-24
|
| pubmed:meshHeading |
pubmed-meshheading:7667184-Alkylation,
pubmed-meshheading:7667184-Animals,
pubmed-meshheading:7667184-Biological Transport,
pubmed-meshheading:7667184-Formaldehyde,
pubmed-meshheading:7667184-Isotope Labeling,
pubmed-meshheading:7667184-Jejunum,
pubmed-meshheading:7667184-Oligonucleotides,
pubmed-meshheading:7667184-Organophosphorus Compounds,
pubmed-meshheading:7667184-Radioligand Assay,
pubmed-meshheading:7667184-Rats,
pubmed-meshheading:7667184-Rats, Sprague-Dawley,
pubmed-meshheading:7667184-Time Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Radiolabeling of methylphosphonate and phosphorothioate oligonucleotides and evaluation of their transport in everted rat jejunum sacs.
|
| pubmed:affiliation |
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill 27599-7365, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|