Linked Life Data

7666126

Source:http://linkedlifedata.com/resource/pubmed/id/7666126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-10-11
pubmed:abstractText
Different natural and semisynthetic polysaccharides were evaluated for their inhibitory effect on in vitro replication of herpes simplex virus (HSV) types 1 and 2. Some neutral and negatively charged carbohydrates were able to inhibit viral infection by interfering mainly with the adsorption process showing a dose-dependent relationship. Their effect was shown within the concentration range of 200-0.8 micrograms/ml, and the inhibiting compounds were in order of action: dextran sulfate = scleroglucan = lambda carrageenan > glyloid sulfate 4324 > locust beam gum towards HSV-1 and dextran sulfate = glyloid sulfate 4324 = lambda carrageenan > scleroglucan > glycogen sulfate 4435 towards HSV-2. The data obtained indicate that the antiviral activity of polysaccharides was not only related to their electric charge. Other characteristics of the molecules such as the polymeric backbone, the carbohydrate moieties and the degree of polymerization could play a role in influencing their antiviral properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1120-009X
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-6
pubmed:dateRevised
2009-8-4
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Inhibition of herpes simplex virus infection by negatively charged and neutral carbohydrate polymers.
pubmed:affiliation
Istituto Pasteur-Fondazione Cenci Bolognetti, Istituto di Microbiologia, Università La Sapienza, Roma, Italy.
pubmed:publicationType
Journal Article