| pubmed-article:7664984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0071216 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0002198 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:7664984 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7664984 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7664984 | pubmed:dateCreated | 1995-10-10 | lld:pubmed |
| pubmed-article:7664984 | pubmed:abstractText | Complex between urokinase and its type-1 inhibitor (uPA-PAI-1) may, when bound to the urokinase receptor (uPAR), be endocytosed by an ensuing binding of the complex to the multiligand receptors alpha (2)-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP) and glycoprotein 330 (gp330). We have found that phorbol esters regulate endocytosis of uPA-PAI-1 differently in different cell lines. In COS-1 cells, expressing uPAR and high levels of alpha 2MR/LRP under basal conditions, phorbol esters cause a time-dependent decrease in endocytosis concomitantly with a parallel down-regulation of alpha 2MR/LRP expression. An up-regulation of uPAR expression was also observed. General endocytosis via the clathrin-coated pit pathway was not affected by PMA treatment, as judged from measurements of transferrin endocytosis. In LLC-PK1 cells, expressing alpha 2MR/LRP but not uPAR under basal conditions, phorbol esters transiently increase endocytosis in parallel with a transient induction of uPAR expression, while there was virtually no change in alpha 2MR/LRP expression. Differential regulation of endocytosis therefore seems to be caused by differential regulation of the receptors, with either the alpha 2MR/LRP-level (in COS)-1 cells) or the uPAR-level (in LLC-PK1 cells) being rate-limiting. | lld:pubmed |
| pubmed-article:7664984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7664984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7664984 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7664984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7664984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7664984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7664984 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7664984 | pubmed:issn | 0303-7207 | lld:pubmed |
| pubmed-article:7664984 | pubmed:author | pubmed-author:AndreasenP... | lld:pubmed |
| pubmed-article:7664984 | pubmed:author | pubmed-author:SimonsenA CAC | lld:pubmed |
| pubmed-article:7664984 | pubmed:author | pubmed-author:EllgaardLL | lld:pubmed |
| pubmed-article:7664984 | pubmed:author | pubmed-author:KjøllerLL | lld:pubmed |
| pubmed-article:7664984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7664984 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7664984 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:7664984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7664984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7664984 | pubmed:pagination | 209-17 | lld:pubmed |
| pubmed-article:7664984 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7664984 | pubmed:meshHeading | pubmed-meshheading:7664984-... | lld:pubmed |
| pubmed-article:7664984 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7664984 | pubmed:articleTitle | Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of alpha 2-macroglobulin receptor and urokinase receptor expression. | lld:pubmed |
| pubmed-article:7664984 | pubmed:affiliation | Department of Molecular Biology, University of Aarhus, Denmark. | lld:pubmed |
| pubmed-article:7664984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7664984 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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