Linked Life Data

7664923

Source:http://linkedlifedata.com/resource/pubmed/id/7664923

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-10-12
pubmed:abstractText
Patulin is immunosuppressive and there is limited evidence of its carcinogenicity in experimental animals. The International Agency for Research on Cancer (IARC) initiated a programme for the development of degradation techniques for the commonly investigated mycotoxins. As a part of this programme, the following techniques were tested for the degradation of patulin: treatment with ammonia, treatment with ascorbic acid, and treatment with potassium permanganate in acidic or in alkaline conditions. Patulin analysis was performed by using HPLC with UV detection. Mutagenic activity of degradation residues was tested by in Salmonella typhimurium strains TA 97a, TA 98, TA 100, and TA 102. Complete disappearance of patulin was not achieved after 92 h of treatment with ascorbic acid. All the other methods tested led to complete removal of the molecule. However, the technique using potassium permanganate in acidic conditions produced residues which were mutagenic without activation to Salmonella typhimurium strains TA 100 and TA 102, which was attributed later to Mn2+. The two other techniques gave satisfactory results and were selected for further validation studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0265-203X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Procedures for destruction of patulin in laboratory wastes.
pubmed:affiliation
CNEVA, Laboratoire Central d'Hygiène Alimentaire, Unité des Toxines Microbiennes, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't