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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1995-10-6
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pubmed:abstractText |
Spontaneous tumorigenesis was evaluated in male p53-knockout (p53-/-) mice treated with dehydroepiandrosterone (DHEA), quercetin, d-limonene, or all-trans retinoic acid to determine whether tumor development in these mice can be modulated by cancer-chemopreventive agents. DHEA-treated mice experienced a delay in tumorigenesis (particularly lymphomas) and subsequent mortality (P < 0.01) relative to untreated control mice. Quercetin, d-limonene, and all-trans retinoic acid each had no effect on spontaneous tumor development in p53-/- mice. These data demonstrate that tumor development in p53-/- mice can be delayed by DHEA and suggest that p53-/- mice provide a useful model for evaluating strategies to offset the increased risk of tumorigenesis resulting from loss of p53 tumor suppressor function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-5472
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
55
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pubmed:geneSymbol |
p53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3949-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7664260-Animals,
pubmed-meshheading:7664260-Anticarcinogenic Agents,
pubmed-meshheading:7664260-Cyclohexenes,
pubmed-meshheading:7664260-Dehydroepiandrosterone,
pubmed-meshheading:7664260-Gene Deletion,
pubmed-meshheading:7664260-Genes, p53,
pubmed-meshheading:7664260-Male,
pubmed-meshheading:7664260-Mice,
pubmed-meshheading:7664260-Mice, Inbred C57BL,
pubmed-meshheading:7664260-Neoplasms,
pubmed-meshheading:7664260-Quercetin,
pubmed-meshheading:7664260-Terpenes,
pubmed-meshheading:7664260-Tretinoin
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pubmed:year |
1995
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pubmed:articleTitle |
Chemoprevention of spontaneous tumorigenesis in p53-knockout mice.
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pubmed:affiliation |
Laboratory of Nutritional and Molecular Regulation, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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