Linked Life Data

7663421

Source:http://linkedlifedata.com/resource/pubmed/id/7663421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-10-10
pubmed:abstractText
Regenerative Sr(++)-induced Sr++ release from isolated rat liver mitochondria was studied using ion-selective electrode techniques. Mitochondria, when exposed to a pulse of Sr++, demonstrated a reversible and transient increase in inner membrane permeability to K+ and H+ ions. The increase in permeability was an all-or-none process with a threshold dependent on the amplitude of the Sr++ pulse. The threshold concentration of Sr++ was lowered from 120-150 microM to 20-30 microM when mitochondria were preloaded with 100 nmoles Sr++/mg protein. Release of matrix-stored divalent cations provided a mechanism for amplification of the extramitochondrial Sr++ concentration (regenerative Sr(++)-induced Sr++ release). The mitochondrial inner membrane became refractory, since subsequent cycles of excitation could not be immediately induced. These experiments demonstrate that the inner mitochondrial membrane is an excitable membrane, with threshold-dependent, regenerative and subsequently refractile Sr(++)-induced Sr++ release characteristics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1039-9712
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-49
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Strontium excitability of the inner mitochondrial membrane: regenerative strontium-induced strontium release.
pubmed:affiliation
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region.
pubmed:publicationType
Journal Article