Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-10-12
|
| pubmed:abstractText |
The mechanism involved in leukemogenesis and neoplastic cell growth of adult T-cell leukemia (ATL) still remains unclear. We examined the tumorigenicity of human T-cell leukemia virus type I (HTLV-I)-infected cell lines in an in vivo cell proliferation model using severe combined immunodeficient (SCID) mice. Eleven HTLV-I-infected cell lines were injected into SCID mice and we found that 4 of them were capable of proliferating in SCID mice. Three of four transplantable cell lines are derived from the leukemic cell clone and 6 of 6 HTLV-I-infected cell lines of nonleukemic cell origin could not engraft in SCID mice. Interestingly, it was shown that some HTLV-I-infected and interleukin-2 (IL-2)-dependent cell lines could successfully engraft in SCID mice. The expression of IL-2 mRNA was not detected in these cell lines growing either in vivo or in vitro. HTLV-I viral products were not detected in 3 of 4 transplantable cell lines proliferating in vivo. Peripheral blood T cells immortalized by introduction of tax gene of HTLV-I were found to have no tumorigenic potential in SCID mice. These data suggest that (1) HTLV-I-infected cell lines of nonleukemic cell origin do not have enough leukemogenic changes to acquire the tumorigenic potential in SCID mice; (2) the IL-2 autocrine mechanism is not directly involved in the tumor cell growth; (3) viral gene expression is not needed for the maintenance of neoplastic cell growth; and (4) the expression of tax gene is not sufficient for the neoplastic cell growth in vivo.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
86
|
| pubmed:geneSymbol |
tax
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2350-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7662981-Animals,
pubmed-meshheading:7662981-Base Sequence,
pubmed-meshheading:7662981-Cell Division,
pubmed-meshheading:7662981-Cell Line,
pubmed-meshheading:7662981-Gene Expression Regulation, Leukemic,
pubmed-meshheading:7662981-Gene Expression Regulation, Viral,
pubmed-meshheading:7662981-Genes, pX,
pubmed-meshheading:7662981-Graft Survival,
pubmed-meshheading:7662981-Immunocompromised Host,
pubmed-meshheading:7662981-Interleukin-2,
pubmed-meshheading:7662981-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:7662981-Lymphoid Tissue,
pubmed-meshheading:7662981-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:7662981-Mice,
pubmed-meshheading:7662981-Mice, SCID,
pubmed-meshheading:7662981-Molecular Sequence Data,
pubmed-meshheading:7662981-Neoplasm Proteins,
pubmed-meshheading:7662981-Neoplasm Transplantation,
pubmed-meshheading:7662981-Neoplastic Stem Cells,
pubmed-meshheading:7662981-Recombinant Proteins,
pubmed-meshheading:7662981-Severe Combined Immunodeficiency,
pubmed-meshheading:7662981-Specific Pathogen-Free Organisms,
pubmed-meshheading:7662981-T-Lymphocytes,
pubmed-meshheading:7662981-Tumor Cells, Cultured
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
|
| pubmed:affiliation |
First Department of Internal Medicine, Kyoto University, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|