Linked Life Data

7662884

Source:http://linkedlifedata.com/resource/pubmed/id/7662884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-10-10
pubmed:abstractText
Freely moving rats were implanted with microdialysis probes in the globus pallidus/ventral pallidum, nucleus accumbens or caudate nucleus. Morphine (10 mg kg-1 i.p.) induced an average 128% increase in extracellular opioid peptide levels in the pallidum over a 2 h period peaking 1 h after injection. No change was observed in the nucleus accumbens or caudate nucleus. Dose-response analysis showed a smaller (26%), non-significant, increase at a lower dose of 2 mg kg-1 and no effect at a higher dose of 40 mg kg-1. No evidence of significant acute tolerance was apparent following repeated administration of morphine (10 mg kg-1, i.p.) at 3 h intervals. The magnitude of the morphine effect varied greatly between animals and was dependent on the pre-injection baseline opioid peptide levels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1093-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release.
pubmed:affiliation
Department of Psychiatry & Biobehavioral Sciences, UCLA School of Medicine 90024-1759, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't