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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 1
|
| pubmed:dateCreated |
1995-10-12
|
| pubmed:abstractText |
Adenosine is a potent arterial vasodilator that, because of a short duration of action and acid lability, is ineffective in the oral treatment of hypertension. Y-341 is a synthetic adenosine analog that is acid stable and has a prolonged duration of action. It is highly selective for the A2 receptor, which is prevalent in the vascular smooth muscle and mediates vasodilation. To determine the efficacy of Y-341 as an antihypertensive agent, the effect of Y-341 on arterial pressure was studied in spontaneously hypertensive rats (SHR) in the awake state, 3 to 4 days after arterial cannulation. Y-341 (3 mg/kg) was dissolved in 5% DMSO and administered by gavage. Blood pressure and heart rate were monitored continuously at predetermined intervals. Fifteen minutes after administration, Y-341 reduced MAP from 180 +/- 4 to 126 +/- 2 mm Hg (n = 9, P < .001). There was no significant change in heart rate. The hypotensive effect was sustained over 8 h. Vehicle (n = 5) had no effect on blood pressure. The hypotensive effect was dose dependent when the dose of Y-341 was increased from 3 to 6 and 12 mg/kg. When Y-341 was administered at 3 mg/kg/day in a single dose for 5 consecutive days, there was no significant change in the magnitude of the hypotensive response over time.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0895-7061
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
509-15
|
| pubmed:dateRevised |
2009-2-24
|
| pubmed:meshHeading |
pubmed-meshheading:7662228-Adenosine,
pubmed-meshheading:7662228-Administration, Oral,
pubmed-meshheading:7662228-Animals,
pubmed-meshheading:7662228-Blood Pressure,
pubmed-meshheading:7662228-Disease Models, Animal,
pubmed-meshheading:7662228-Heart Rate,
pubmed-meshheading:7662228-Hypertension,
pubmed-meshheading:7662228-Kidney,
pubmed-meshheading:7662228-Rats,
pubmed-meshheading:7662228-Rats, Inbred SHR,
pubmed-meshheading:7662228-Rats, Sprague-Dawley,
pubmed-meshheading:7662228-Receptors, Purinergic P1
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
The hypotensive effect of an oral adenosine analog with selectivity for the A2 receptor in the spontaneously hypertensive rat.
|
| pubmed:affiliation |
Department of Nephrology and Hypertension, Barzilai Medical Center, Ashkelon, Israel.
|
| pubmed:publicationType |
Journal Article
|