Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-10-3
|
| pubmed:abstractText |
We performed a study to determine a reference range for serum alpha 1-antitrypsin (alpha 1AT) in dogs by specific immunoassay; to evaluate whether serum alpha 1AT concentration varied with age, sex, or reproductive status in healthy dogs; and to investigate whether the serum alpha 1AT concentration in hospitalized dogs differed from that of healthy, nonhospitalized dogs. Serum alpha 1AT was quantitated by radial gel immuno-diffusion for 60 healthy dogs and 311 hospitalized dogs. In healthy dogs, serum alpha 1AT concentration was 2.33 +/- 0.41 mg/ml (mean +/- SD), yielding a reference range (mean +/- 2 SD) of 1.51 to 3.15 mg/ml. A correlation was not found between serum alpha 1AT concentration and age in healthy dogs. The serum alpha 1AT concentration (mean +/- SEM mg/ml) was significantly higher in healthy, sexually intact females (2.64 +/- 0.1) than in healthy, spayed females (2.22 +/- 0.12; P < 0.004); healthy, sexually intact males (2.14 +/- 0.1; P < 0.0006); and healthy, and castrated males (2.25 +/- 0.14; P < 0.02). Hospitalized, sexually intact females had a lower serum alpha 1AT concentration (1.93 +/- 0.07) than healthy, sexually intact females (2.64 +/- 0.1; P < 0.0002). Likewise, the serum alpha 1AT concentration in hospitalized, sexually intact males (1.92 +/- 0.04) was less than in healthy, sexually intact males (2.14 +/- 0.1; P < 0.04). A difference in alpha 1AT concentration was not found between healthy and hospitalized, neutered dogs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0002-9645
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
568-72
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7661449-Age Factors,
pubmed-meshheading:7661449-Animals,
pubmed-meshheading:7661449-Dog Diseases,
pubmed-meshheading:7661449-Dogs,
pubmed-meshheading:7661449-Female,
pubmed-meshheading:7661449-Immunodiffusion,
pubmed-meshheading:7661449-Male,
pubmed-meshheading:7661449-Orchiectomy,
pubmed-meshheading:7661449-Ovariectomy,
pubmed-meshheading:7661449-Reference Values,
pubmed-meshheading:7661449-Sex Factors,
pubmed-meshheading:7661449-alpha 1-Antitrypsin
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Effects of age, sex, reproductive status, and hospitalization on serum alpha 1-antitrypsin concentration in dogs.
|
| pubmed:affiliation |
Center for Veterinary Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
|
| pubmed:publicationType |
Journal Article
|