Linked Life Data

7660786

Source:http://linkedlifedata.com/resource/pubmed/id/7660786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-10-4
pubmed:abstractText
The hemodynamic changes of metoprolol (Met, 50 mg.kg-1.d-1, po, 3 wk) withdrawal for 1 day and the effects of nifedipine (Nif) and m-nifedipine (m-Nif) on these changes were observed in pressure overload hypertrophy in rats by abdominal aortic constriction for 4 wk. Both Nif and m-Nif (10 mg.kg-1.d-1, respectively, po, 3 wk) significantly attenuated the increase of MAP (from 14.3 +/- 2.3 to 12.9 +/- 2.3 and 11.3 +/- 2.4 kPa, respectively, n = 6-7, P < 0.05) and decrease the abnormal development of systolic function of left ventricle after Met withdrawal. Radioreceptor assay indicates that Nif and m-Nif can prevent the up-regulation of myocardium beta-receptors in left ventricular hypertrophy and large dose of Met exposure for a long time. These results suggest that calcium antagonists administered with beta-blockers can prevent beta-receptor blocker withdrawal syndrome.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0513-4870
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Effects of calcium antagonists on withdrawal of beta-receptor blockers in rats during left ventricular hypertrophy].
pubmed:affiliation
Department of Cardiovascular Pharmacology, Nanjing Medical University.
pubmed:publicationType
Journal Article, English Abstract