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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1995-10-4
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pubmed:abstractText |
With the emergence of widespread chloroquine resistance and a world-wide scarcity of quinine, a search for newer antimalarial drugs has become imperative. Different derivatives of qinghaosu have been successfully tried. alpha,beta-Arteether, an ethyl derivative of qinghaosu, was administered to 51 patients with Plasmodium falciparum malaria, in a dose of 150 mg intramuscularly once a day on 3 consecutive days. Complete parasite clearance from the peripheral blood was observed in 80% of the patients at 48 h and in 98% at 72 h. The median parasite clearance time was 2 d (range 1-4 d). 65% of the patients became afebrile within 48 h and 81% by 72 h. The mean fever clearance time was 52.04 h (standard deviation 27.09). No side effect was seen. Patients were followed-up for 4 weeks; 7 were readmitted with P. falciparum infection but it could not be ascertained definitely whether these cases were reinfections or recrudescences. alpha-beta Arteether was a safe, effective and convenient drug for treating P. falciparum malaria. This is the first clinical study with arteether in falciparum malaria.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0035-9203
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-301
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7660441-Adolescent,
pubmed-meshheading:7660441-Adult,
pubmed-meshheading:7660441-Aged,
pubmed-meshheading:7660441-Animals,
pubmed-meshheading:7660441-Antimalarials,
pubmed-meshheading:7660441-Artemisinins,
pubmed-meshheading:7660441-Female,
pubmed-meshheading:7660441-Humans,
pubmed-meshheading:7660441-India,
pubmed-meshheading:7660441-Malaria, Falciparum,
pubmed-meshheading:7660441-Male,
pubmed-meshheading:7660441-Middle Aged,
pubmed-meshheading:7660441-Plasmodium falciparum,
pubmed-meshheading:7660441-Sesquiterpenes
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pubmed:articleTitle |
Effectiveness of alpha,beta-arteether in acute falciparum malaria.
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pubmed:affiliation |
Department of Internal Medicine, Ispat General Hospital, Rourkela, Orissa, India.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Clinical Trial, Phase II
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