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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1995-10-4
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pubmed:abstractText |
Excessive calcium entry into depolarized neurons contributes significantly to cerebral tissue damage after ischemia. We evaluated the ability of a novel neuronal calcium channel blocker, SB 201823-A, to block central neuronal calcium influx in vitro and to reduce ischemic injury in two rodent models of focal stroke.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1683-9; discussion 1689-90
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7660415-Animals,
pubmed-meshheading:7660415-Blood Pressure,
pubmed-meshheading:7660415-Calcium,
pubmed-meshheading:7660415-Calcium Channel Blockers,
pubmed-meshheading:7660415-Calcium Channels,
pubmed-meshheading:7660415-Cells, Cultured,
pubmed-meshheading:7660415-Cerebellum,
pubmed-meshheading:7660415-Cerebral Infarction,
pubmed-meshheading:7660415-Disease Models, Animal,
pubmed-meshheading:7660415-Glycine,
pubmed-meshheading:7660415-Hippocampus,
pubmed-meshheading:7660415-Ischemic Attack, Transient,
pubmed-meshheading:7660415-Male,
pubmed-meshheading:7660415-Mice,
pubmed-meshheading:7660415-Mice, Inbred Strains,
pubmed-meshheading:7660415-N-Methylaspartate,
pubmed-meshheading:7660415-Neurons,
pubmed-meshheading:7660415-Neuroprotective Agents,
pubmed-meshheading:7660415-Patch-Clamp Techniques,
pubmed-meshheading:7660415-Piperidines,
pubmed-meshheading:7660415-Potassium Chloride,
pubmed-meshheading:7660415-Rats,
pubmed-meshheading:7660415-Rats, Inbred F344,
pubmed-meshheading:7660415-Rats, Inbred Strains,
pubmed-meshheading:7660415-Rats, Sprague-Dawley
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pubmed:year |
1995
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pubmed:articleTitle |
SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice.
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pubmed:affiliation |
SmithKline Beecham Pharmaceuticals, King of Prussia, Pa 19406-0939, USA.
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pubmed:publicationType |
Journal Article
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