Linked Life Data

7660062

Source:http://linkedlifedata.com/resource/pubmed/id/7660062

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-10-4
pubmed:abstractText
The macrophage scavenger receptor (MSR) is a multipotent receptor that mediates uptake of macromolecules with clustered negative charges, such as endotoxins and oxidized proteins and lipoproteins. It may also serve as an adhesion molecule for monocytes and macrophages. We have analysed MSR expression in human peripheral lymph nodes and show, by reverse transcription-PCR, that the type I isoform of MSR is abundantly expressed in this tissue. With the use of a new set of isoform-specific peptide antibodies, both isoforms of MSR were detected in the cuboidal endothelium of high-endothelial venules (HEV). MSR antibodies also stained macrophages and follicular dendritic cells of germinal centres. These data indicate that the MSR gene is expressed in HEV endothelium in vivo. It is suggested that MSR expression may be important for antigen uptake and leucocyte adhesion to HEV in the lymph node.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-96
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
High endothelial cells of postcapillary venules express the scavenger receptor in human peripheral lymph nodes.
pubmed:affiliation
Institute of Laboratory Medicine, Gothenburg University, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't