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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-10-4
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pubmed:abstractText |
In vivo interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-gamma production was measured at the mRNA transcript and protein levels in patients acutely infected with Plasmodium falciparum and during convalescence. Both IL-10 and IFN-gamma but not IL-2 were produced regardless of the patients' clinical severity. IL-4 production was variable. Circulating IFN-gamma and IL-10 were significantly higher in patients with severe disease (P < .01 and .001, respectively). In vitro stimulation of peripheral blood mononuclear cells (PBMC) by malarial antigens during acute infection showed that although there was no lymphoproliferation, the cells could produce IL-10 and IFN-gamma. Recombinant human IL-10 completely abolished in vitro tumor necrosis factor (TNF)-alpha production in response to malarial antigens, as well as the antigen-specific proliferative response of convalescent patients. However, anti-IL-10 was insufficient to restore proliferation of PBMC from acutely infected patients. These findings suggest that IL-10 may have an important negative feedback action on the production of inflammatory cytokines in acute falciparum malaria without contributing to the defect in antigen-specific proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
838-44
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7658079-Adult,
pubmed-meshheading:7658079-Animals,
pubmed-meshheading:7658079-Antigens, Protozoan,
pubmed-meshheading:7658079-Cells, Cultured,
pubmed-meshheading:7658079-Convalescence,
pubmed-meshheading:7658079-DNA Probes,
pubmed-meshheading:7658079-Gene Expression,
pubmed-meshheading:7658079-Humans,
pubmed-meshheading:7658079-Interferon-gamma,
pubmed-meshheading:7658079-Interleukin-10,
pubmed-meshheading:7658079-Interleukin-2,
pubmed-meshheading:7658079-Interleukin-4,
pubmed-meshheading:7658079-Interleukins,
pubmed-meshheading:7658079-Lymphocyte Activation,
pubmed-meshheading:7658079-Lymphocytes,
pubmed-meshheading:7658079-Malaria, Falciparum,
pubmed-meshheading:7658079-Plasmodium falciparum,
pubmed-meshheading:7658079-Polymerase Chain Reaction,
pubmed-meshheading:7658079-RNA, Messenger,
pubmed-meshheading:7658079-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
Interleukin-10 inhibits tumor necrosis factor production but not antigen-specific lymphoproliferation in acute Plasmodium falciparum malaria.
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pubmed:affiliation |
Department of Microbiology and Infectious Diseases, University of Calgary, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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