Linked Life Data

7658050

Source:http://linkedlifedata.com/resource/pubmed/id/7658050

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-9-29
pubmed:abstractText
The aim of this study was to test genotoxicity aspects of the safety of two strains of Bacillus thuringiensis. The strains were of serotype H-1, producing thuringiensin, toxic to flies, and serotype H-14, producing endotoxin, toxic to mosquitoes, but not thuringiensin. Four preparations were tested: Tenfold concentrated cell-free culture media of serotypes H-1 and H-14, prepurified thuringiensin, and purified endotoxin. No increases in revertant colony numbers of the tester strains of Salmonella typhimurium TA98 or TA100 were observed at the dose levels used with or without metabolic activation. Infrequent slight increases in revertant colony numbers in strains TA98 and TA1538 at a very high test dose of 50 mg/plate, both in the presence and absence of thuringiensin, were probably caused by histidine present in the growth medium of B. thuringiensis. Furthermore, the effects were at most slightly dose related and not reproducible, and therefore the preparations can be considered nonmutagenic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2011
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Safety testing of Bacillus thuringiensis preparations, including thuringiensin, using the Salmonella assay.
pubmed:affiliation
Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't