| pubmed-article:7656023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7656023 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:7656023 | lifeskim:mentions | umls-concept:C0026377 | lld:lifeskim |
| pubmed-article:7656023 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:7656023 | lifeskim:mentions | umls-concept:C0045883 | lld:lifeskim |
| pubmed-article:7656023 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7656023 | pubmed:dateCreated | 1995-10-5 | lld:pubmed |
| pubmed-article:7656023 | pubmed:abstractText | One- and two-dimensional NMR shows that the carcinogen 2-aminofluorene exists in two unique, interchangeable conformations when covalently bound to a model human c-H-ras1 proto-oncogene codon 61 oligomer duplex. In one conformation the 2-aminofluorene moiety protrudes out of the major groove leaving the Watson-Crick base pairing of the cytosine and 2-aminofluorene-guanine bases intact, consistent with the ability of replicating enzymes to bypass the lesion and correctly incorporate cytosine. The second form of the modified oligomer duplex may be representative of a pre-mutagenic conformation in that the 2-aminofluorene moiety is stacked within the DNA helix, disrupting base pairing between the 2-aminofluorene-modified guanine and its complementary cytosine. | lld:pubmed |
| pubmed-article:7656023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7656023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7656023 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7656023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7656023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7656023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7656023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7656023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7656023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7656023 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7656023 | pubmed:issn | 1072-8368 | lld:pubmed |
| pubmed-article:7656023 | pubmed:author | pubmed-author:KrughT RTR | lld:pubmed |
| pubmed-article:7656023 | pubmed:author | pubmed-author:EckelL MLM | lld:pubmed |
| pubmed-article:7656023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7656023 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:7656023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7656023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7656023 | pubmed:pagination | 89-94 | lld:pubmed |
| pubmed-article:7656023 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7656023 | pubmed:meshHeading | pubmed-meshheading:7656023-... | lld:pubmed |
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| pubmed-article:7656023 | pubmed:meshHeading | pubmed-meshheading:7656023-... | lld:pubmed |
| pubmed-article:7656023 | pubmed:meshHeading | pubmed-meshheading:7656023-... | lld:pubmed |
| pubmed-article:7656023 | pubmed:meshHeading | pubmed-meshheading:7656023-... | lld:pubmed |
| pubmed-article:7656023 | pubmed:meshHeading | pubmed-meshheading:7656023-... | lld:pubmed |
| pubmed-article:7656023 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7656023 | pubmed:articleTitle | 2-Aminofluorene modified DNA duplex exists in two interchangeable conformations. | lld:pubmed |
| pubmed-article:7656023 | pubmed:affiliation | Department of Chemistry, University of Rochester, New York 14627, USA. | lld:pubmed |
| pubmed-article:7656023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7656023 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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