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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-10-5
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pubmed:abstractText |
One- and two-dimensional NMR shows that the carcinogen 2-aminofluorene exists in two unique, interchangeable conformations when covalently bound to a model human c-H-ras1 proto-oncogene codon 61 oligomer duplex. In one conformation the 2-aminofluorene moiety protrudes out of the major groove leaving the Watson-Crick base pairing of the cytosine and 2-aminofluorene-guanine bases intact, consistent with the ability of replicating enzymes to bypass the lesion and correctly incorporate cytosine. The second form of the modified oligomer duplex may be representative of a pre-mutagenic conformation in that the 2-aminofluorene moiety is stacked within the DNA helix, disrupting base pairing between the 2-aminofluorene-modified guanine and its complementary cytosine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1072-8368
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7656023-Base Sequence,
pubmed-meshheading:7656023-Binding Sites,
pubmed-meshheading:7656023-Carcinogens,
pubmed-meshheading:7656023-Codon,
pubmed-meshheading:7656023-DNA Adducts,
pubmed-meshheading:7656023-Fluorenes,
pubmed-meshheading:7656023-Genes, ras,
pubmed-meshheading:7656023-Humans,
pubmed-meshheading:7656023-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7656023-Models, Molecular,
pubmed-meshheading:7656023-Molecular Sequence Data,
pubmed-meshheading:7656023-Molecular Structure,
pubmed-meshheading:7656023-Mutagenesis,
pubmed-meshheading:7656023-Nucleic Acid Conformation,
pubmed-meshheading:7656023-Thermodynamics
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pubmed:year |
1994
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pubmed:articleTitle |
2-Aminofluorene modified DNA duplex exists in two interchangeable conformations.
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pubmed:affiliation |
Department of Chemistry, University of Rochester, New York 14627, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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