Linked Life Data

7654779

Source:http://linkedlifedata.com/resource/pubmed/id/7654779

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-10-2
pubmed:abstractText
The effect on lipoprotein metabolism of diets enriched in different isomers of dioleoylpalmitoylglycerol was studied. One diet contained fat in which palmitate was esterified to the two outer positions of the glycerol (OOP) and the other in which it was esterified to the middle carbon (OPO). The lipid composition of chylomicrons was similar in rats fed either fat blend. However, triacylglycerol (TAG) in chylomicrons from OPO fed animals was relatively enriched in palmitic acid, at the expense of stearic, oleic and linoleic acids. Silver phase HPLC and 2-positional analysis clearly demonstrated that the identity of the fatty acid in the 2-position was similar in both dietary and chylomicron TAG. No significant differences could be seen in the in vitro hydrolysis of chylomicron TAG from animals fed the two fats labelled with [14C]palmitate. As expected, following hydrolysis, palmitate was released as free fatty acid from chylomicrons isolated from OOP-fed animals but within 2-monoacylglycerol from those fed OPO. The enrichment of chylomicrons with palmitate in animals fed O[14C]PO resulted in increased delivery of [14C]palmitate to the liver. In a further series of experiments Golden Syrian hamsters were fed diets containing the fat blends and either 0.005% or 0.12% (w/w) cholesterol, for 28 days. No differences in fasting plasma lipoprotein concentrations were seen in response to the dietary fats. We conclude that, while these isometric triacylglycerols had transient effects on chylomicron metabolism, no significant longer term effect on plasma concentrations of endogenous lipoproteins could be found.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
1258
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effect of dietary triacylglycerol structure on lipoprotein metabolism: a comparison of the effects of dioleoylpalmitoylglycerol in which palmitate is esterified to the 2- or 1(3)-position of the glycerol.
pubmed:affiliation
Department of Applied Biochemistry and Food Science, University of Nottingham, Loughborough, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't