Linked Life Data

7654485

Source:http://linkedlifedata.com/resource/pubmed/id/7654485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-9-29
pubmed:abstractText
1. Hair samples were obtained from subjects at the end of a 6 month smoking-cessation programme carried out with (n = 16) or without (n = 10) the aid of nicotine chewing gum. The axial distribution of nicotine along the hair shaft was determined and compared both with the self-report of smoking behavior and with the concentration of carbon monoxide (CO) in expired air measured at 1 month intervals. 2. A gradual decrease in nicotine content along the hair shaft corresponded to the decrease in self-reported number of cigarettes smoked daily in both the nicotine chewing-gum treated and untreated subjects and with the clinical assessment of abstinence. 3. There was reasonable agreement between the CO content of expired air, the self-reported number of cigarettes smoked daily and the axial distribution of nicotine in 22 of 26 subjects. In the other four subjects there was an apparent disagreement between the CO content of expired air and the other parameters. 4. This study showed that, as a routine marker of smoking status, hair analysis may be preferable to repeated CO measurements since only a single sample at the end of an abstinence programme might be sufficient. However, one problem is that nicotine may dissociate slowly from melanin to limit the ability to mark a sudden cessation of smoking. Also, some nicotine in hair might be attributable to nicotine adsorbed to the outside of hair.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-1286440, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-1432873, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-1485377, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-1619568, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-2353827, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-3824275, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-4042325, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-7859809, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8138226, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8179658, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8245279, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8359180, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8403740, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8411605, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654485-8503145
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The axial distribution of nicotine content along hair shaft as an indicator of changes in smoking behaviour: evaluation in a smoking-cessation programme with or without the aid of nicotine chewing gum.
pubmed:affiliation
Department of Pharmacology, Gifu University School of Medicine, Japan.
pubmed:publicationType
Journal Article