7654198

Source:http://linkedlifedata.com/resource/pubmed/id/7654198

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0009325, umls-concept:C0016030, umls-concept:C0017262, umls-concept:C0018270, umls-concept:C0086418, umls-concept:C0162745, umls-concept:C0851285
pubmed:dateCreated	1995-9-27
pubmed:abstractText	Platelet-derived growth factor (PDGF) is a mitogen associated with tissue repair, a process involving collagen synthesis and remodelling by interstitial collagenase. This study examines and compares the regulation of interstitial collagenase and collagen gene expression by PDGF-AA and -BB in human fibroblasts. Time-course analysis showed that neither PDGF-AA or -BB had a consistent effect on the expression of pro-alpha 1(I) or pro-alpha 2(I) type-I collagen genes. In contrast, interstitial collagenase gene expression was found to be consistently up-regulated severalfold by PDGF-BB. Enhanced expression of the collagenase gene was not apparently due to up-regulation of its promoter activity in human dermal fibroblasts, as indicated by transient and stable transfection experiments. Unlike PDGF-BB, PDGF-AA did not alter collagenase mRNA levels under low-serum culture conditions. Thus, the biological activities of the PDGF homodimers are different, with PDGF-BB being clearly more potent than PDGF-AA in its regulation of collagenase gene expression.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AR41048-01A1
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-1280116, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-1315403, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-1325456, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-1494293, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-1665062, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-1846446, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2045423, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2157183, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2343305, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2508504, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2542295, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2840203, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2987824, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-2987965, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-3009463, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-3013421, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-3124113, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-4705382, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-6159641, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-6183642, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-6687691, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-6896909, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-6960240, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-7681410, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-8300745, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-8319603, http://linkedlifedata.com/resource/pubmed/commentcorrection/7654198-8486774
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2984726R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Collagen, http://linkedlifedata.com/resource/pubmed/chemical/Collagenases, http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Procollagen, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor A, http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor BB
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0264-6021
pubmed:author	pubmed-author:FoxJ WJW4th, pubmed-author:KennedyS HSH, pubmed-author:MooreJ HJHJr, pubmed-author:QinHH, pubmed-author:RoudaSS, pubmed-author:TanE MEM
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	310 ( Pt 2)
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	585-8
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:7654198-Cells, Cultured, pubmed-meshheading:7654198-Collagen, pubmed-meshheading:7654198-Collagenases, pubmed-meshheading:7654198-Dose-Response Relationship, Drug, pubmed-meshheading:7654198-Fibroblasts, pubmed-meshheading:7654198-Gene Expression Regulation, pubmed-meshheading:7654198-Gene Expression Regulation, Enzymologic, pubmed-meshheading:7654198-Humans, pubmed-meshheading:7654198-Keloid, pubmed-meshheading:7654198-Kinetics, pubmed-meshheading:7654198-Platelet-Derived Growth Factor, pubmed-meshheading:7654198-Procollagen, pubmed-meshheading:7654198-Promoter Regions, Genetic, pubmed-meshheading:7654198-Recombinant Proteins, pubmed-meshheading:7654198-Reference Values, pubmed-meshheading:7654198-Skin, pubmed-meshheading:7654198-Time Factors
pubmed:year	1995
pubmed:articleTitle	Platelet-derived growth factors-AA and -BB regulate collagen and collagenase gene expression differentially in human fibroblasts.
pubmed:affiliation	Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.