Linked Life Data

7654007

Source:http://linkedlifedata.com/resource/pubmed/id/7654007

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-9-28
pubmed:abstractText
The stability of sodium 5,6-benzylidene-L-ascorbate (SBA), consisting of two diastereomers, was investigated by high-performance liquid chromatography. In extensively acidic buffer, the acetal in SBA was immediately cleaved to liberate ascorbic acid and benzaldehyde. At higher pH, the cleavage of SBA was significantly reduced, but the degradation (due to possible opening of the lactone ring) of SBA was stimulated. The degradation rate of SBA was significantly increased with increasing temperature, and was higher than that of ascorbic acid or benzaldehyde. SBA was degraded with incubation time in culture medium, with accompanying loss of its biological activity, but only a marginal concentration of benzaldehyde, but not of ascorbic acid, was produced from SBA. The amount of SBA extracted from the apoptosing leukemic cells by 70% acetonitrile amounted to about 0.04% of that present in the medium fraction. These data suggest that SBA itself, but not contaminating ascorbic acid nor benzaldehyde, is responsible for the antitumor activity of SBA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1269-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Stability of sodium 5,6-benzylidene-L-ascorbate.
pubmed:affiliation
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't