| pubmed-article:7653592 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7653592 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:7653592 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7653592 | lifeskim:mentions | umls-concept:C0005847 | lld:lifeskim |
| pubmed-article:7653592 | lifeskim:mentions | umls-concept:C0083536 | lld:lifeskim |
| pubmed-article:7653592 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:7653592 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:7653592 | pubmed:issue | 2 Pt 2 | lld:pubmed |
| pubmed-article:7653592 | pubmed:dateCreated | 1995-9-22 | lld:pubmed |
| pubmed-article:7653592 | pubmed:abstractText | The impact of chronic NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension (20 mg.kg-1.day-1 po, for 25 days) on pressure responsiveness was assessed in vessels ranging from arcuate arteries (ArcA) to juxtaglomerular afferent arterioles (JAA), using videomicroscopy and blood-perfused juxtamedullary nephron (JMN) preparations. Respective tail-cuff pressures of control and L-NAME rats were 127 +/- 2 (n = 8) and 173 +/- 4 mmHg (n = 5). Corresponding vessels of both groups had similar calibers at 60 mmHg. Increasing blood perfusion pressure to 200 mmHg constricted control ArcA and JAA by 26 +/- 4% (n = 20) and 43 +/- 5% (n = 15), respectively. Instead, a respective 3 +/- 4% (n = 15) and 21 +/- 9% (n = 6) pressure-induced dilation occurred in L-NAME vessels, and 86 +/- 2% of glomeruli expressed alpha-smooth muscle actin. Responses to acetylcholine (1 microM) but not to nitroprusside (1 mM) were impaired by L-NAME. Maximal relaxation induced by Mn2+ (10 mM) revealed equal basal tone and similar passive viscoelastic properties in control and L-NAME vessels. No vascular hypertrophy was found in L-NAME vessels. Chronic L-NAME hypertension is therefore associated with a selective loss of vascular autoregulation in JMNs, which may contribute to glomerular injury. | lld:pubmed |
| pubmed-article:7653592 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7653592 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653592 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7653592 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653592 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653592 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653592 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7653592 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7653592 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7653592 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7653592 | pubmed:author | pubmed-author:CasellasDD | lld:pubmed |
| pubmed-article:7653592 | pubmed:author | pubmed-author:BouriquetNN | lld:pubmed |
| pubmed-article:7653592 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7653592 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7653592 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7653592 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7653592 | pubmed:pagination | F190-7 | lld:pubmed |
| pubmed-article:7653592 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7653592 | pubmed:meshHeading | pubmed-meshheading:7653592-... | lld:pubmed |
| pubmed-article:7653592 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7653592 | pubmed:articleTitle | Chronic L-NAME hypertension in rats and autoregulation of juxtamedullary preglomerular vessels. | lld:pubmed |
| pubmed-article:7653592 | pubmed:affiliation | Groupe Rein et Hypertension, Hôpital St. Charles, Montpellier, France. | lld:pubmed |
| pubmed-article:7653592 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7653592 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7653592 | lld:pubmed |
