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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2 Pt 2
|
| pubmed:dateCreated |
1995-9-22
|
| pubmed:abstractText |
The impact of chronic NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension (20 mg.kg-1.day-1 po, for 25 days) on pressure responsiveness was assessed in vessels ranging from arcuate arteries (ArcA) to juxtaglomerular afferent arterioles (JAA), using videomicroscopy and blood-perfused juxtamedullary nephron (JMN) preparations. Respective tail-cuff pressures of control and L-NAME rats were 127 +/- 2 (n = 8) and 173 +/- 4 mmHg (n = 5). Corresponding vessels of both groups had similar calibers at 60 mmHg. Increasing blood perfusion pressure to 200 mmHg constricted control ArcA and JAA by 26 +/- 4% (n = 20) and 43 +/- 5% (n = 15), respectively. Instead, a respective 3 +/- 4% (n = 15) and 21 +/- 9% (n = 6) pressure-induced dilation occurred in L-NAME vessels, and 86 +/- 2% of glomeruli expressed alpha-smooth muscle actin. Responses to acetylcholine (1 microM) but not to nitroprusside (1 mM) were impaired by L-NAME. Maximal relaxation induced by Mn2+ (10 mM) revealed equal basal tone and similar passive viscoelastic properties in control and L-NAME vessels. No vascular hypertrophy was found in L-NAME vessels. Chronic L-NAME hypertension is therefore associated with a selective loss of vascular autoregulation in JMNs, which may contribute to glomerular injury.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
269
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
F190-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7653592-Actins,
pubmed-meshheading:7653592-Animals,
pubmed-meshheading:7653592-Arginine,
pubmed-meshheading:7653592-Blood Pressure,
pubmed-meshheading:7653592-Blood Vessels,
pubmed-meshheading:7653592-Chronic Disease,
pubmed-meshheading:7653592-Hemodynamics,
pubmed-meshheading:7653592-Homeostasis,
pubmed-meshheading:7653592-Hypertension,
pubmed-meshheading:7653592-Juxtaglomerular Apparatus,
pubmed-meshheading:7653592-Male,
pubmed-meshheading:7653592-Muscle, Smooth, Vascular,
pubmed-meshheading:7653592-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:7653592-Nitric Oxide,
pubmed-meshheading:7653592-Rats,
pubmed-meshheading:7653592-Rats, Wistar,
pubmed-meshheading:7653592-Renal Circulation
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Chronic L-NAME hypertension in rats and autoregulation of juxtamedullary preglomerular vessels.
|
| pubmed:affiliation |
Groupe Rein et Hypertension, Hôpital St. Charles, Montpellier, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|