rdf:type |
|
lifeskim:mentions |
umls-concept:C0014839,
umls-concept:C0026809,
umls-concept:C0439810,
umls-concept:C0687080,
umls-concept:C1007825,
umls-concept:C1280500,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2698332,
umls-concept:C2752151,
umls-concept:C2828366
|
pubmed:issue |
2
|
pubmed:dateCreated |
1995-9-26
|
pubmed:abstractText |
This study investigates the total ethanol extract (TE) of the stem bark of Fraxinus ornus and its constituent esculin (EN). They inhibited classical pathway (CP) and alternative pathway (AP) of complement activation in mouse serum. After intraperitoneal administration the total extract displayed antiinflammatory activity in both zymosan- and carrageenan-induced paw oedema in mice. The results suggest that the traditional use of Fraxinus ornus stem bark extracts in the treatment of inflammatory disorders is at least partially due to its coumarin constituents.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0378-8741
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
46
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
101-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7650947-Animals,
pubmed-meshheading:7650947-Bulgaria,
pubmed-meshheading:7650947-Carrageenan,
pubmed-meshheading:7650947-Complement Activation,
pubmed-meshheading:7650947-Complement Hemolytic Activity Assay,
pubmed-meshheading:7650947-Complement Inactivator Proteins,
pubmed-meshheading:7650947-Disease Models, Animal,
pubmed-meshheading:7650947-Edema,
pubmed-meshheading:7650947-Esculin,
pubmed-meshheading:7650947-Ethanol,
pubmed-meshheading:7650947-Hindlimb,
pubmed-meshheading:7650947-Injections, Intraperitoneal,
pubmed-meshheading:7650947-Mice,
pubmed-meshheading:7650947-Plant Extracts,
pubmed-meshheading:7650947-Trees,
pubmed-meshheading:7650947-Zymosan
|
pubmed:year |
1995
|
pubmed:articleTitle |
Effect of a total extract from Fraxinus ornus stem bark and esculin on zymosan- and carrageenan-induced paw oedema in mice.
|
pubmed:affiliation |
Department of Immunology, Bulgarian Academy of Sciences, Sofia.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|