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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1995-9-22
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pubmed:databankReference |
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pubmed:abstractText |
The expression of certain MHC class I allotypes by potential target cells can inhibit NK cell-mediated cytotoxicity. We recently identified the NKB1 surface Ag, expressed on T and NK cell subsets, as a putative inhibitory receptor for HLA-B class I molecules possessing the Bw4 serologic epitope. NKB1 is a 70-kDa glycoprotein that after deglycosylation migrates as a 50-kDa protein as determined by SDS-PAGE. A cDNA encoding the NKB1 receptor was cloned from a NKB1+T cell cDNA library by expression in COS-7 cells using the anti-NKB1 mAb DX9. NKB1 is a member of the lg superfamily containing three lg-like domains in the extracellular region and is related to the recently identified family (p58/NKAT) of human NK and T cell surface molecules that appear to function as inhibitory receptors for HLA class I.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/KIR2DL3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR3DL1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR3DS1
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2306-10
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7650366-Amino Acid Sequence,
pubmed-meshheading:7650366-Base Sequence,
pubmed-meshheading:7650366-Blotting, Southern,
pubmed-meshheading:7650366-Chromosome Mapping,
pubmed-meshheading:7650366-Clone Cells,
pubmed-meshheading:7650366-Cloning, Molecular,
pubmed-meshheading:7650366-DNA, Complementary,
pubmed-meshheading:7650366-Gene Expression,
pubmed-meshheading:7650366-HLA-B Antigens,
pubmed-meshheading:7650366-Humans,
pubmed-meshheading:7650366-Killer Cells, Natural,
pubmed-meshheading:7650366-Molecular Sequence Data,
pubmed-meshheading:7650366-RNA, Messenger,
pubmed-meshheading:7650366-Receptors, Immunologic,
pubmed-meshheading:7650366-Receptors, KIR,
pubmed-meshheading:7650366-Receptors, KIR2DL3,
pubmed-meshheading:7650366-Receptors, KIR3DL1,
pubmed-meshheading:7650366-Receptors, KIR3DS1,
pubmed-meshheading:7650366-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.
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pubmed:affiliation |
Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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