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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-9-28
|
| pubmed:abstractText |
We investigated, in 20 patients with Graves' disease and presenting with both a surgically induced hypothyroid state and increased serum antibodies (Ab) to the TSH receptor (R) levels, the relationships between thyroid status and the serum TSH-R or peroxidase (TPO) Ab levels under L-T4 treatment and after L-T4 cessation. The prevalence of positive TSH-R Ab (100%) and the log mean TSH-R Ab level (1.41 +/- 0.04%) observed during the surgically induced hypothyroid state decreased (p < 0.001, p < 0.01, respectively) under L-T4 therapy (prevalence of positive TSH-R Ab = 50%, log mean TSH-R Ab level 1.21 +/- 0.05%) and increased again (p < 0.001) after L-T4 cessation (prevalence of positive TSH-R Ab = 85%, log mean TSH-R Ab level = 1.45 +/- 0.06%) to reach levels lower (< 0.01) than that observed during the hypothyroid state for prevalence of positive TSH-R Ab but similar to that obtained during such a state for log mean TSH-R Ab value. The log mean TPO Ab level obtained during the surgically induced hypothyroid state (3.2 +/- 0.5 titer) decreased (p < 0.02) under L-T4 therapy (1.8 +/- 0.2 titer) and increased again (p < 0.02) after L-T4 cessation (3.0 +/- 0.5 titer) to reach a similar level to that obtained during the surgically induced hypothyroid state. There were positive correlations between log TSH levels and log TSH-R Ab values (r = 0.40, p < 0.001) or log TPO Ab levels (r = 0.33, p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-0163
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
29-34
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7649524-Adult,
pubmed-meshheading:7649524-Autoantibodies,
pubmed-meshheading:7649524-Autoimmunity,
pubmed-meshheading:7649524-Female,
pubmed-meshheading:7649524-Graves Disease,
pubmed-meshheading:7649524-Humans,
pubmed-meshheading:7649524-Hypothyroidism,
pubmed-meshheading:7649524-Iodide Peroxidase,
pubmed-meshheading:7649524-Male,
pubmed-meshheading:7649524-Middle Aged,
pubmed-meshheading:7649524-Prospective Studies,
pubmed-meshheading:7649524-Receptors, Thyrotropin,
pubmed-meshheading:7649524-Thyroidectomy
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Effects of thyroid status on thyroid autoimmunity expression in surgically induced hypothyroid patients with Graves' disease.
|
| pubmed:affiliation |
Department of Endocrinology, Saint-Michel Hospital, Paris, France.
|
| pubmed:publicationType |
Journal Article
|