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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-9-28
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pubmed:abstractText |
We studied the extent of functional linkage between CD3 sigma and p56lck in pre-TCR-dependent thymocyte development. Differentiation of DN to DP cells was examined by treatment of RAG2/CD3 sigma and RAG1/p56lck double-deficient mice with anti-CD3 epsilon antibodies. The results suggest that CD3 sigma has no specific role in this maturation step, but may be important for amplification of signaling through the pre-TCR. In contrast, p56lck is the main protein tyrosine kinase associated with signaling through the pre-TCR-CD3 complex. In DP thymocytes, the Ca2+ response to anti-CD3 epsilon was totally abolished in CD3 sigma-I-but only reduced in p56lck-I-mice, and in vivo responses to anti-CD3 epsilon differed from one another. Thus, CD3 sigma and p56lck are functionally not tightly associated and their deficiencies cause distinct developmental defects.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-22
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7648394-Animals,
pubmed-meshheading:7648394-Antigens, CD3,
pubmed-meshheading:7648394-Antigens, CD4,
pubmed-meshheading:7648394-Antigens, CD8,
pubmed-meshheading:7648394-Base Sequence,
pubmed-meshheading:7648394-Calcium,
pubmed-meshheading:7648394-Cell Differentiation,
pubmed-meshheading:7648394-DNA Primers,
pubmed-meshheading:7648394-Flow Cytometry,
pubmed-meshheading:7648394-Homeodomain Proteins,
pubmed-meshheading:7648394-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:7648394-Mice,
pubmed-meshheading:7648394-Molecular Sequence Data,
pubmed-meshheading:7648394-Protein-Tyrosine Kinases,
pubmed-meshheading:7648394-Proteins,
pubmed-meshheading:7648394-Receptors, Interleukin-2,
pubmed-meshheading:7648394-Signal Transduction,
pubmed-meshheading:7648394-T-Lymphocytes,
pubmed-meshheading:7648394-Thymus Gland
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pubmed:year |
1995
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pubmed:articleTitle |
Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection.
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pubmed:affiliation |
Max Planck Institut für Immunobiologie, Freiburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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