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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-9-26
|
| pubmed:abstractText |
The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at microM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
573-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7648205-Antineoplastic Agents,
pubmed-meshheading:7648205-Drug Screening Assays, Antitumor,
pubmed-meshheading:7648205-Humans,
pubmed-meshheading:7648205-Porphyrins,
pubmed-meshheading:7648205-Solubility,
pubmed-meshheading:7648205-Structure-Activity Relationship,
pubmed-meshheading:7648205-Water
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity.
|
| pubmed:affiliation |
Department of Chemistry and Biochemistry, University of Texas at Austin 78712, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|