Linked Life Data

7647369

Source:http://linkedlifedata.com/resource/pubmed/id/7647369

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-9-26
pubmed:abstractText
The GE2270 complex consists mainly of GE2270 A (MW 1289), a thiazolyl peptide antibiotic whose structure originates from the modification of a chain of 14 amino acids in a process which creates six thiazole rings and one pyridine. Together with the main component, a number of structurally related molecules are co-produced in small quantities by fermentation. A preparative high-performance liquid chromatrography method was developed to isolate GE2270 factors B1, B2, C1, C2a, C2b, D1, D2, E and T. Their structures, preliminarily determined by 1H-nuclear magnetic resonance spectroscopy in comparison with GE2270 A, were confirmed by low and high resolution fast-atom bombardment mass spectrometry and studies on the intact molecules and on their main hydrolysis products. Their molecular weights range from 1246 to 1306 Da. The structural differences between the factors lie in the extent of methylation and/or oxidation of thiazole rings (D and E) and asparagine, and in the aromatization of the oxazoline ring.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0951-4198
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
717-22
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Contribution of mass spectrometry to the structural confirmation of components of the antibiotic GE2270 complex.
pubmed:affiliation
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (VARESE), Italy.
pubmed:publicationType
Journal Article