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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1995-9-15
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pubmed:abstractText |
7-[(2,2-Dimethyl)propyl]-1-methyl xanthine (CAS 155006-67-0, MX2/120) is a new potent antibronchospastic agent with negligible side effects. The synthesis involves the alkylation of 3-benzyl-1-methyl xanthine with neopentyl bromide followed by removal of the benzyl protecting group. Main physico-chemical properties were determined using NMR, MS, IR, UV spectra and X-ray crystal structure. A quantitative determination of substances related to MX2/120 and of residual solvents by means of HPLC and GC, respectively, is described. MX2/120 is safely stored at room temperature for a long time.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
684-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7646571-Bronchodilator Agents,
pubmed-meshheading:7646571-Chemistry, Physical,
pubmed-meshheading:7646571-Chromatography, Gas,
pubmed-meshheading:7646571-Chromatography, High Pressure Liquid,
pubmed-meshheading:7646571-Crystallography, X-Ray,
pubmed-meshheading:7646571-Drug Stability,
pubmed-meshheading:7646571-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7646571-Mass Spectrometry,
pubmed-meshheading:7646571-Physicochemical Phenomena,
pubmed-meshheading:7646571-Solubility,
pubmed-meshheading:7646571-Spectrophotometry, Infrared,
pubmed-meshheading:7646571-Spectrophotometry, Ultraviolet,
pubmed-meshheading:7646571-Xanthines
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pubmed:year |
1995
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pubmed:articleTitle |
Synthesis and analytical profile of the new potent antibronchospastic agent 7-[(2,2-dimethyl)propyl]-1-methyl xanthine.
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pubmed:affiliation |
Istituto Farmacobiologico Malesci S.p.A., Research Laboratories, Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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