Linked Life Data

7646542

Source:http://linkedlifedata.com/resource/pubmed/id/7646542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-9-19
pubmed:abstractText
The effect of histamine on [3H]norepinephrine ([3H]NE) release in uterine horns from mice in estrous and diestrous states was studied under two different experimental conditions: resting NE release and stimulus-evoked NE release. It was found that [3H]NE release was higher for the diestrous state under both resting and stimulus-evoked (100 mM K+ and electrical stimulus) conditions. Histamine only potentiated the stimulus-evoked [3H]NE outflow in uterine horns from mice in the diestrous state and from ovariectomized mice treated with progesterone. This effect was dose dependent and was antagonized by H1 but not by H2 or H3 antagonists. R-alpha-Methylhistamine, a H3 agonist, has no effect on stimulus-evoked [3H]NE release. According to these results, it could be concluded that: (a) histamine regulates the NE release from noradrenergic nerve terminals in uterine tissues; (b) this heterologous regulation depends on progesterone predominance and on terminal depolarization; and (c) presynaptic H1 receptors located on noradrenergic terminals could be responsible for such an effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Histamine, a neuromodulator of noradrenergic transmission in uterine horns from mice in diestrus.
pubmed:affiliation
Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't