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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1995-9-21
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pubmed:databankReference |
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pubmed:abstractText |
We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-1377222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-1537606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-1688611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-1694221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-1840703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-2108859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-2437578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-2568889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-2785681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-3162770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-3782828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-3819393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-6157763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7513441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7522162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7801122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7805731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7836932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7875194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7878657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7895173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-7903287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8006593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8022805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8113668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8113684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8125142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8164742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8170938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8221640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8340755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8370389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7644523-8505985
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7976-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7644523-Alleles,
pubmed-meshheading:7644523-Amino Acid Sequence,
pubmed-meshheading:7644523-Antigens, Neoplasm,
pubmed-meshheading:7644523-Base Sequence,
pubmed-meshheading:7644523-Binding, Competitive,
pubmed-meshheading:7644523-Cell Line,
pubmed-meshheading:7644523-Cloning, Molecular,
pubmed-meshheading:7644523-Cytotoxicity, Immunologic,
pubmed-meshheading:7644523-Exons,
pubmed-meshheading:7644523-Humans,
pubmed-meshheading:7644523-Introns,
pubmed-meshheading:7644523-Kinetics,
pubmed-meshheading:7644523-Melanoma,
pubmed-meshheading:7644523-Molecular Sequence Data,
pubmed-meshheading:7644523-Mutagenesis,
pubmed-meshheading:7644523-Neoplasm Proteins,
pubmed-meshheading:7644523-Point Mutation,
pubmed-meshheading:7644523-Recombinant Proteins,
pubmed-meshheading:7644523-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7644523-Transfection,
pubmed-meshheading:7644523-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, UCL 7459, Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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