Linked Life Data

7644127

Source:http://linkedlifedata.com/resource/pubmed/id/7644127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-9-18
pubmed:abstractText
Since electrical stimulation of neurones may activate not only cell bodies but also neuronal fibres, this study aimed to test a selectively cholinergic neurochemical stimulation of the rat substantia innominata (SI) by the local microinjection of carbachol; the effects of this acetylcholine agonist were compared with glutamate. Cortical and subcortical cerebral blood flow (CBF) were measured in anaesthetized rats with the [14C]iodoantipyrine method by the tissue sampling technique immediately following the intracerebral (SI) microinjection of saline, 50 nmol of carbachol or glutamate. Carbachol microinjection into the SI induced a transient but significant vasodilation in frontoparietal motor (+28%) and temporal (+41%) cortices, that lasted for less than 10 min. Glutamate did not elicit any significant CBF modifications when compared to control rats although a significant interhemispheric asymmetry after microinjection was observed in the frontoparietal motor cortex. This latter observation would suggest that the glutamate-induced cortical response is less pronounced than that elicited by carbachol. Overall, these results demonstrate that a selective cholinergic stimulation of the SI can induce a transient cortical vasodilation and further confirms the hypothesis of a muscarinic modulation of CBF via this basal structure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
190
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Regional cerebral blood flow responses to neurochemical stimulation of the substantia innominata in the anaesthetized rat.
pubmed:affiliation
University of Caen, URA 1829 CNRS, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't