Linked Life Data

7644122

Source:http://linkedlifedata.com/resource/pubmed/id/7644122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-9-18
pubmed:abstractText
Auditory evoked responses recorded from the CA3 region of the rat hippocampus show diminished response to repeated stimuli, suggesting the activity of an inhibitory gating mechanism. The effects on this putative gating mechanism of two GABAB receptor antagonists, CGP35348 and CGP46381, were characterized in a conditioning testing paradigm. Both compounds, administered intracerebroventricularly, antagonized the suppression of response to the test stimulus. The results are consistent with the hypothesis that this inhibitory gating of response involves GABAB receptors, which may control the release of glutamate from excitatory pathways in the hippocampus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
190
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
GABAB antagonists diminish the inhibitory gating of auditory response in the rat hippocampus.
pubmed:affiliation
Department of Pharmacology, Veterans Administration Medical Center, Denver, CO, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.