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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1995-9-20
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pubmed:abstractText |
Based on reports that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk for Alzheimer's disease (AD), we studied the cross-sectional relation between NSAID use and the risk for AD in a population-based study of disease and disability in older people. After controlling for age, education, gender, and use of benzodiazepines, we found a relative risk (RR) for AD of 0.38 (0.15 to 0.95) when comparing NSAID users (n = 365) to NSAID non-users (n = 5,893). To address confounding by indication or contraindication, we compared NSAID users with a subset of NSAID non-users who were using topical medication for ear, eye, or dermatologic conditions (n = 365). In this comparison, the adjusted RR for AD was 0.54 (0.16 to 1.78). These findings are compatible with a possible protective effect of NSAIDs on the risk for AD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-3878
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
1441-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7644037-Aged,
pubmed-meshheading:7644037-Alzheimer Disease,
pubmed-meshheading:7644037-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:7644037-Cross-Sectional Studies,
pubmed-meshheading:7644037-Female,
pubmed-meshheading:7644037-Humans,
pubmed-meshheading:7644037-Male,
pubmed-meshheading:7644037-Middle Aged,
pubmed-meshheading:7644037-Risk Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|