Linked Life Data

7643965

Source:http://linkedlifedata.com/resource/pubmed/id/7643965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-9-21
pubmed:abstractText
Although generally accepted to play an important role in development, the precise functional significance of NCAM remains to be elucidated. Correlative and interventive studies suggest a role for polysialylated NCAM in neurite elaboration. In the adult NCAM polysialylation continues to be expressed in regions of the central nervous system which retain neuroplastic potential. During memory formation modulation of polysialylation on the synapse-enriched isoform of NCAM occurs in the hippocampus. The polysialylated neurons of this structure have been located at the border of the granule cell layer and hilar region of the dentate and their number increases dramatically during memory consolidation. The converse is also true for a profound decline in the basal number of polysialylated neurons occurs with ageing when neural plasticity becomes attenuated. In conclusion, it is suggested that NCAM polysialylation regulates ultrastructural plasticity associated with synaptic elaboration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
593-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Polysialylation as a regulator of neural plasticity in rodent learning and aging.
pubmed:affiliation
Department of Pharmacology, University College, Belfield, Dublin, Ireland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't