Linked Life Data

7643528

Source:http://linkedlifedata.com/resource/pubmed/id/7643528

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-9-20
pubmed:abstractText
GATA-3 is a transcription factor involved in the differentiation of T lymphocytes and additionally expressed in several chicken and mouse embryonic tissues. Using in situ hybridization, we found that the human GATA-3 gene is selectively expressed in the developing kidney. GATA-3 mRNA is first detected in the Wolffian duct from the time of its emergence in the embryonic intermediate mesoderm and further expressed in the collecting ducts of the mesonephros until its involution. In the metanephros, GATA-3 is expressed in the ureteric bud where it is constitutively transcribed, throughout development, along the branching process that gives rise to the whole collecting system of the definitive kidney. Besides the Wolffian duct and derivatives, we also report the expression of GATA-3 gene in the glomerular mesangium and adjacent endocapillary cells, in both meso- and metanephros. This early and specific expression of the GATA-3 gene suggests a role for this transcription factor in the differentiation of the human kidney.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1597-603
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The GATA-3 gene is expressed during human kidney embryogenesis.
pubmed:affiliation
Institut d'Embryologie Cellulaire et Moléculaire, Nogent-sur-Marne, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't