Linked Life Data

7643170

Source:http://linkedlifedata.com/resource/pubmed/id/7643170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-9-18
pubmed:abstractText
1. We have stimulated responses of stellate cells in the anteroventral cochlear nucleus (AVCN) to single-formant stimuli (SFSs) with the use of recorded auditory-nerve fiber (ANF) responses as inputs. In particular, two important features of temporal discharge patterns, the phase locking to best frequency (BF) tones and to stimulus envelopes, were examined in the model output. Our earlier experimental studies with SFSs found an enhancement of the envelope modulation in AVCN chopper units, presumably recorded from stellate cells, as compared with that of ANFs. 2. We simulated in the model three mechanisms for the enhancement in envelope modulation proposed earlier by us, namely, convergence of ANFs, temporal summation and inhibitory input. It was found that the convergence of multiple ANFs alone did not always lead to an enhancement in modulation depth, but was necessary for the model to produce other physiologically plausible envelope features; the temporal summation of subthreshold events can lead to an increase in modulation depth; and the somatic inhibition effectively reduced the envelope minimum and, as a result, increased the modulation depth. In addition, we found that, given the same input configuration, the closer the inputs were located to the soma, the greater modulation depth they produced at the model output. 3. Different types of convergence of ANF inputs were tested in our model. It was found that the convergence of both low and high spontaneous rate (SR) ANFs resulted in an enhancement in modulation depth over a wider range of sound level than that due to the convergence of ANFs from the same SR group.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3077
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1600-16
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Transformation of temporal discharge patterns in a ventral cochlear nucleus stellate cell model: implications for physiological mechanisms.
pubmed:affiliation
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.