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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1995-9-21
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pubmed:abstractText |
The T-cell and antibody responses to a cell surface streptococcal antigen (SA I/II) were investigated in naturally sensitized humans. Serum antibody responses were directed predominantly to the N-terminal (residues 39 to 481) and central (residues 816 to 1213) regions of SA I/II which may be involved in bacterial adhesion to salivary receptors. T-cell responses were also directed predominantly towards the central region. The linear peptide relationship of the immunodominant and minor T- and B-cell as well as adhesion epitopes was mapped within residues 816 to 1213. Immunodominant T-cell and B-cell epitopes were identified within residues 803 to 853, which were separated in linear sequence from the adhesion epitopes (residues 1005 to 1044). Adhesion epitopes overlapped with minor B- and T-cell epitopes (residues 1005 to 1054 and 1085 to 1134). An immunodominant promiscuous T-cell epitope (residues 985 to 1004) was adjacent to an adhesion epitope (residues 1005 to 1024). The limited B-cell response to adhesion epitopes is consistent with the success of Streptococcus mutans in colonizing the oral cavity. The strategy of T-cell, adhesion, and B-cell epitope mapping has revealed a general approach for identifying components of subunit vaccines which may focus responses to critical functional determinants. Such epitopes of SA I/II may constitute the components of a subunit vaccine against dental caries.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7642303-104924,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3649-58
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7642303-Amino Acid Sequence,
pubmed-meshheading:7642303-Antigens, Bacterial,
pubmed-meshheading:7642303-Antigens, Surface,
pubmed-meshheading:7642303-B-Lymphocytes,
pubmed-meshheading:7642303-Bacterial Adhesion,
pubmed-meshheading:7642303-Base Sequence,
pubmed-meshheading:7642303-Dental Caries,
pubmed-meshheading:7642303-Epitope Mapping,
pubmed-meshheading:7642303-Humans,
pubmed-meshheading:7642303-Lymphocyte Activation,
pubmed-meshheading:7642303-Molecular Sequence Data,
pubmed-meshheading:7642303-Recombinant Proteins,
pubmed-meshheading:7642303-Streptococcus mutans,
pubmed-meshheading:7642303-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
T-cell, adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II.
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pubmed:affiliation |
Department of Immunology, United Medical School at Guy's Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article
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