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rdf:type |
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lifeskim:mentions |
umls-concept:C0009015,
umls-concept:C0020792,
umls-concept:C0034819,
umls-concept:C0205314,
umls-concept:C0242210,
umls-concept:C0337112,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0679622,
umls-concept:C1149222,
umls-concept:C1524075,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2003941
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pubmed:issue |
15
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pubmed:dateCreated |
1995-9-15
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pubmed:databankReference |
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pubmed:abstractText |
Interleukin-15 (IL-15) is a novel cytokine of the four-helix bundle family which shares many biological activities with IL-2, probably due to its interaction with the IL-2 receptor beta and gamma (IL-2R beta and gamma c) chains. We report here the characterization and molecular cloning of a distinct murine IL-15R alpha chain. IL-15R alpha alone displays an affinity of binding for IL-15 equivalent to that of the heterotrimeric IL-2R for IL-2. A biologically functional heteromeric IL-15 receptor complex capable of mediating IL-15 responses was generated through reconstruction experiments in a murine myeloid cell line. IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-145543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-1558969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-1698558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-1956801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2006136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2147944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2155425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2440696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2555171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2590941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2827008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-2970865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-3005322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-3011033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-3095922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-3135551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-3555973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-3929255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-6096720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-6235287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-6373375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-7523571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-7759105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-7814861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-7973658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8026467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8128231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8178155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8197161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8266076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8266077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8266078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8392875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8462096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8476561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8499634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7641685-8503926
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3654-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7641685-Animals,
pubmed-meshheading:7641685-Mice,
pubmed-meshheading:7641685-Cell Division,
pubmed-meshheading:7641685-Base Sequence,
pubmed-meshheading:7641685-RNA, Messenger,
pubmed-meshheading:7641685-Amino Acid Sequence,
pubmed-meshheading:7641685-Organ Specificity,
pubmed-meshheading:7641685-Solubility,
pubmed-meshheading:7641685-Lymphocyte Activation,
pubmed-meshheading:7641685-Cell Line,
pubmed-meshheading:7641685-Molecular Sequence Data,
pubmed-meshheading:7641685-Cloning, Molecular,
pubmed-meshheading:7641685-Sequence Homology, Amino Acid,
pubmed-meshheading:7641685-Sequence Analysis, DNA,
pubmed-meshheading:7641685-T-Lymphocytes, Cytotoxic
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