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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-9-21
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pubmed:abstractText |
The isoenzyme Mu of glutathione S-transferase (GSTM1) is dominantly inherited, and the prevalence of this isoenzyme in the population is about 60%. The lack of GSTM1 has been linked with cancer risk. The frequency of the phenotypes of this isoenzyme in melanoma (MM) patients (n = 197) is reported here. A significantly higher proportion of individuals in the control group (n = 147) had measurable GSTM1 than MM patients (59.1% vs 42%, P = 0.002); there was a higher proportion of positive phenotypes in general among women than among men. Odds ratio analysis indicated that individuals with this polymorphic variant have an approximately 2-fold risk of developing these cancers. GSTM1 phenotype distribution depends on age, smoking habit and tumour pathology. A group of MM patients with dysplastic naevi was also studied.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-1864525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-1875044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-2001549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-2007784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-2297503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-2671699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-3698203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-3768372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-3947517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-3967184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-7905099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-8422649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-8439946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7640212-8507665
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7640212-Adult,
pubmed-meshheading:7640212-Aged,
pubmed-meshheading:7640212-Antioxidants,
pubmed-meshheading:7640212-Female,
pubmed-meshheading:7640212-Glutathione Transferase,
pubmed-meshheading:7640212-Humans,
pubmed-meshheading:7640212-Isoenzymes,
pubmed-meshheading:7640212-Male,
pubmed-meshheading:7640212-Melanoma,
pubmed-meshheading:7640212-Middle Aged,
pubmed-meshheading:7640212-Neoplasms, Radiation-Induced,
pubmed-meshheading:7640212-Phenotype,
pubmed-meshheading:7640212-Reactive Oxygen Species,
pubmed-meshheading:7640212-Reference Values,
pubmed-meshheading:7640212-Risk Factors,
pubmed-meshheading:7640212-Ultraviolet Rays
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pubmed:year |
1995
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pubmed:articleTitle |
Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group.
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pubmed:affiliation |
Institute de Salut Pública, Universitat de Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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