Linked Life Data

7639762

Source:http://linkedlifedata.com/resource/pubmed/id/7639762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-9-11
pubmed:abstractText
In this report we demonstrate that rats maintained on a calcium supplemented vitamin D3-deficient diet for nine weeks showed an increase in heart to body weight ratio. Morphometric analysis indicated that vitamin D3 deficiency produced cardiac myocytes that were smaller yet more numerous, indicating hyperplasia. Western blot analysis showed that vitamin D3 deficiency also resulted in increased c-myc protein levels in the hearts of vitamin D3-deficient rats. Furthermore, 1,25-dihydroxyvitamin D3 reduced c-myc protein levels in primary cultures of ventricular myocytes from neonatal rat hearts. Our data suggest a possible relationship between myocyte hyperplasia and increased c-myc levels in the vitamin D3-deficient rat heart.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
213
pubmed:geneSymbol
c-myc
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
1,25-Dihydroxyvitamin D3 regulation of myocardial growth and c-myc levels in the rat heart.
pubmed:affiliation
Department of Pharmacology, University of Michigan, Ann Arbor 48109-0626, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't