Linked Life Data

7639748

Source:http://linkedlifedata.com/resource/pubmed/id/7639748

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-9-11
pubmed:abstractText
Deficiency of dystrophin, a 427-kDa subsarcolemma membrane protein, is responsible for Duchenne muscular dystrophy. The function of this protein is not clear but its subcellular distribution suggests that it is an important link between the cytoskeleton and the extracellular matrix, thus maintaining membrane integrity. The N-terminus of dystrophin was shown to bind actin in vivo and in vitro via two major actin binding sites. The role of dystrophin/actin interactions has been investigated and the results presented here demonstrate for the first time that the N-terminal part of dystrophin is able (i) to interact with G-actin monomers, and (ii) to slowly promote G->F actin transformation. This conversion was shown to be stimulated the presence of calmodulin in a calcium dependent manner. This is evidence that dystrophin is an anchor protein for actin involved in the control of membrane cell shape deformation and developing a calmodulin-calcium induced F-actin network, thus stiffening the myotube membrane cytoskeleton.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-301
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Dystrophin, the protein that promotes membrane resistance.
pubmed:affiliation
INSERM U 300, Faculté de Pharmacie, Montpellier, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't