Linked Life Data

7639728

Source:http://linkedlifedata.com/resource/pubmed/id/7639728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-9-11
pubmed:abstractText
The CGCG tetranucleotides are clustered inside the CpG islands in the genomes of vertebrates. In order to study the distribution of the islands in the human chromosome we have mapped the loci sensitive to the CGCG specific restriction nuclease, in a 1.5 Mb long DNA segment cloned as Yeast Artificial Chromosome (YAC). The sites most sensitive to Bsh 1236 I nuclease show chromosomal loop-size spacing. This result, as well as the result of nucleotide sequence analysis of long genomic segments, suggests that the CGCG are organised in clusters (not always undermethylated) which are coincident with GC peaks on the sine wave-like curve representing DNA composition along the mammalian chromosome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Loop-size spacings between CGCG clusters in long segments of human DNA.
pubmed:affiliation
Laboratoire de Mutagénèse Institut J. Monod, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't