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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1995-9-12
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pubmed:abstractText |
In a prospective double-blind study, we examined the effects of preoperative epidural morphine associated with general anesthesia (GA) on intra- and postoperative analgesic requirements over a 3-day postoperative period. Twenty patients scheduled for major intraabdominal surgery were randomly assigned to two groups: a control group (n = 10) and an epidural group (n = 10) which received an epidural injection of 5 mg of preservative-free morphine in 10 mL of 0.9% saline. Afterward, both groups received the same GA. Postoperative pain relief was achieved with intravenous (IV) boluses of morphine using a patient-controlled analgesia device. We found smaller opioid requirements in the epidural group than in the control group for intraoperative fentanyl (465 +/- 179 micrograms vs 983 +/- 682 micrograms), for postoperative morphine at 12 h (3.1 +/- 3 mg vs 21.4 +/- 13.8 mg) and 24 h (9.1 +/- 6.4 mg vs 20.6 +/- 9.8 mg), and for the cumulated needs over the 3-day postoperative period (37 +/- 24 mg vs 86 +/- 42 mg). The consumption of IV morphine by the control group decreased over time (P < 0.001, r = 0.44), whereas, in the epidural group, consumption remained constant and small during the 3 days. The maximum pain score was significantly lower in the epidural group than in the control group at 24 h (0.65 +/- 2.4 vs 3 +/- 2), at 36 h (0.3 +/- 0.6 vs 3 +/- 2.7), and at 60 h (0.1 +/- 0.3 vs 1.8 +/- 1.2) after surgery. These results suggest that a single epidural injection of 5 mg of morphine before major surgery produces intra- and postoperative pain relief for at least 3 days.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0003-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
298-302
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7639368-Adult,
pubmed-meshheading:7639368-Aged,
pubmed-meshheading:7639368-Analgesia, Epidural,
pubmed-meshheading:7639368-Double-Blind Method,
pubmed-meshheading:7639368-Female,
pubmed-meshheading:7639368-Humans,
pubmed-meshheading:7639368-Male,
pubmed-meshheading:7639368-Middle Aged,
pubmed-meshheading:7639368-Morphine,
pubmed-meshheading:7639368-Pain, Postoperative,
pubmed-meshheading:7639368-Premedication,
pubmed-meshheading:7639368-Prospective Studies,
pubmed-meshheading:7639368-Treatment Outcome
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pubmed:year |
1994
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pubmed:articleTitle |
Preoperative analgesia with epidural morphine.
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pubmed:affiliation |
Département d'Anesthésie-Réanimation, Université Paris Sud, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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