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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-9-13
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pubmed:abstractText |
Endotoxin (lipopolysaccharide [LPS]) stimulation of tissue-fixed macrophages induces the generation of toxic oxidants. However, recent studies also implicate redox changes in both the signal transduction pathways for cytokine genes and the generation of physiologically active arachidonic acid metabolites. Because cytokines and arachidonic acid metabolites initiate and perpetuate deleterious systemic inflammatory responses, we tested whether macrophage activation could be modulated by antioxidants.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
412-20
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:7638759-Acetylcysteine,
pubmed-meshheading:7638759-Animals,
pubmed-meshheading:7638759-Antioxidants,
pubmed-meshheading:7638759-Blood Coagulation Factors,
pubmed-meshheading:7638759-Dinoprostone,
pubmed-meshheading:7638759-Endotoxins,
pubmed-meshheading:7638759-Macrophages, Alveolar,
pubmed-meshheading:7638759-Male,
pubmed-meshheading:7638759-Rabbits,
pubmed-meshheading:7638759-Tumor Necrosis Factor-alpha,
pubmed-meshheading:7638759-Vitamin E
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pubmed:year |
1995
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pubmed:articleTitle |
Antioxidants attenuate endotoxin-induced activation of alveolar macrophages.
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pubmed:affiliation |
Department of Surgery, University of Washington, Seattle 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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